Ewha Med J.
1989 Dec;12(4):241-251. 10.12771/emj.1989.12.4.241.
The Morphologic Study of Vitamin A(Retinol) on 1, 2-Dimethylhydrazine Induced Colon Carcinogenesis in the Rats
- Affiliations
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- 1Department of Pathology, Collee of Medicine, Ewha Womans University, Korea.
- KMID: 1965796
- DOI: http://doi.org/10.12771/emj.1989.12.4.241
Abstract
- Induction of intestinal tumor by subcutaneous injection of 1, 2-dimethylhydrazine(DMH), 20 mg/kg/week, during 20 weeks was studied in rats fed by vitamin A(retinol) 50 microg, 500 microg/day. Mucosal epithelial cell hyperplasia and mitosis in one crypt was not significantly inhibited by vitamin A administration(P>0.05). In electron microscopic findings, the cytoplasmic vacuoles were decreased in DMH+vitamin A-treated rats than DMH only. Dysplasia of the colonic mucosa in DMH+vitamin A-treated group were more slowly developed than DMH-treated rats. In DMH-treated rats the tumors were early detected after 14 weeks, but in DMH+vitamin A-treated groups were seen after 20 weeks. All these findings suggest that vitamin A can effectively prevent cytotoxicity of carcinogen in early phase, but can not prevent carcinogenesis in late phase.
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