Ewha Med J.  1997 Jun;20(2):209-215. 10.12771/emj.1997.20.2.209.

Morphologic Study of Effect of Fosfomycin and Pentoxifylline on Cisplatin Induced Ototoxicity in Guinea Pig

• Kim CD
• Hong SK

• KMID: 1964778
• DOI: http://doi.org/10.12771/emj.1997.20.2.209

Abstract

OBJECTIVES
The use of cis-platinum as therapeutic drug in malignant neoplasm has associated side effects such as nephrotoxicity and ototoxicity. The nephrotoxic effects of this drug is decreased by use of hydration method. The ototoxic effect, however, cause a irreversible sensorineural hearing loss and incidence of ototoxicity is not changed, so prevention of ototoxic effect is important.
METHODS
The efficacies of fosfomycin, agent in ameliorating cisplatin induced ototoxicity, are investigated in guinea pig cochleas and the effects of pentoxifylline, agent in therapeutic drug of idiopathic sensorineural hearing loss, are evaluated anatomically by cochlear histology with scanning eletromicroscopy.
RESULTS
Protection against the distortion and injury of outer hair cell according to position of the cochlea caused by cicplatin was statistically significant in groups injected with fosfomycin. Also the injury of hair cells seen in groups injected with both pentoxifyllin and cisplatin was significantly higher than that of cisplatin only group.
CONCLUSION
Fosfomycin protects against cisplatin induced ototoxicity but pentoxifylline does not protect cesplatin induced ototoxicity.

Keyword

Ototoxicity; Cisplatin; Fosfomycin; Pentoxifylline

MeSH Terms

Animals
Cisplatin*
Cochlea
Fosfomycin*
Guinea Pigs*
Hair
Hearing Loss, Sensorineural
Incidence
Pentoxifylline*
Cisplatin
Fosfomycin
Pentoxifylline