J Korean Assoc Maxillofac Plast Reconstr Surg.  2002 Nov;24(6):457-463.

A Immunohistochemical Study Of Proliferating Cell Nuclear Antigen(Pcna) In Oral Malignant Melanoma

• Hwang KG
• Nam YW
• Lee JI
• Lee JH
• Shim KS
• Kim MJ

Abstract

Malignant melanoma arising from the mucosa of head and neck region was rare and showed poor prognosis.Some of malignant melanoma were transformed from benign melanotic lesion.Malignant melanoma had high cellular proliferation and rapid growth. The percentage of PCNA-positive cell (labeling index) is high in many malignant tumor. So we compared the pattern of PCNA expression in the melanotic lesion. We performed the immunohistochemical study in malignant melanoma (19 cases), benign melanotic macule (24 cases) and normal mucosa(20 cases) were diagnosed in Seoul National University Dental Hospital between 1980 and 2000. Positive PCNA staining was found mainly in malignant melanoma.The mean PCNA expression in malignant melanoma, melanotic macule, normal tissue were 29.2 %, 1.4 %, 0 %, respectively.Significant differences in PCNA expression were noted between malignant melanoma and melanotic macule(p<0.01),normal mucosa(p<0.01). These result suggested that the PCNA expression seems to be used as a diagnostic indicator for malignancy in malignant melanoma and melanotic lesion.

Keyword

PCNA,Malignant melanoma; Immunohistochemical Staining

MeSH Terms

Cell Proliferation
Head
Melanoma*
Mucous Membrane
Neck
Proliferating Cell Nuclear Antigen
Seoul
Proliferating Cell Nuclear Antigen