J Korean Androl Soc.  1995 Dec;13(2):149-152.

Effectiveness of High-Dose Ketoconazole in Preventing Postoperative Penile Erection

• Paik SH
• Yang DY

Abstract

Nocturnal erections are androgen dependent. Ketoconazole, a synthetic imidazole dioxulane, reduces adrenal and testicular androgen production in man. To determine if ketoconazole can prevent postoperative spontaneous erections in patients undergoing penile surgery, we administered 400mg of the drug every 8 hours to 18 patients. No spontaneous erections were observed postoperatively in 16 patients. In 17 cases, serum testosterone concentrations were below 20ng/dL 24 to 28 hours affer initiation of therapy. Once ketoconazole was discontinued, serum testosterone concentrations returned to baseline within 48 hours. Transient hepatotoxicity was observed in two patients, but liver function tests returned to normal within 2 weeks.

MeSH Terms

Humans
Ketoconazole*
Liver Function Tests
Male
Penile Erection*
Testosterone
Ketoconazole
Testosterone