J Korean Neurol Assoc.
1992 Sep;10(3):324-330.
Tc-99m HMPAO SPECT in Olivopontocerebellar Atrophy
- Affiliations
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- 1Department of Neurology, College of Medicine, Chungbuk National University.
- 2Department of Neurology, College of Medicine, Seoul National University.
- 3Department of Nuclear Medicine, College of Medicine, Seoul National University.
Abstract
- We studied local cerebral blood flow with Tc-99m HMPAO SPECT in 15 patients with olivopontocerebellar atrophy(OPCA) and 15 age-matched control subjects without neurological desease. The diagnosis of OPCA was based upon the history and physical findings and upon the exclusion of other cerebellar ataxia by means of laboratory investigations. Computed tomographic scan and MRI revealed some degree of atrophy of the cerebellum in most patient with OPCA, and many also had atrophy of the brain stem. SPECT studies in these patients revealed decreased cerebral blood flow in the cerebellum in comparison with the normal control subjects(p<0.001). Two patients with minimal atrophy or no structural changes in the cerebellum also showed decreased perfusion. Tc-99m HMPAO SPECT may be useful as a diagnostic test in patients with OPCA. Some instances suggest that Tc-99m HMPAO SPECT may show abnormal finding earlier than other neuroimaging methods.
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