J Korean Neurosurg Soc.
2007 Jun;41(6):408-410.
Paradoxical Deterioration of Intramedullary Spinal Tuberculomas during Antituberculous Therapy
- Affiliations
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- 1Department of Neurosurgery, National Medical Center, Seoul, Korea. chsjwa@hanmail.net
Abstract
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"Paradoxical deterioration" during antituberculous therapy is generally defined as the clinical or radiological worsening of pre-existing tuberculous lesions or the development of new lesions in a patient who initially improves. The phenomenon of paradoxical deterioration in intramedullary tuberculoma of the spinal cord is rare and is a less established entity. The authors present an unusual case of paraparesis as a result of paradoxical deterioration of intramedullary tuberculoma despite adequate antituberculous therapy. Here, we review the relevant literatures and discuss its possible pathogenic mechanisms.