J Korean Ophthalmol Soc.
1997 Jul;38(7):1194-1202.
Experimental Branch Retinal Vein Occlusion in Albino Rats
- Affiliations
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- 1Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
- 2Department of Ophthalmology, Samsung Medical CenterChangs Eye Clinic, Incheon, Korea.
Abstract
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The retinal vein occlusion is one of the most common retinal diseases, and the establishment of animal model in rats will be a great help for further study. We occluded branch retinal veins with rose bengal dye injection followed by argon-green laser photocoagulation in albino rats. Retinal vein occlusion was maintained over 1 day in 35 eyes out of 47, maximally over 5 days. Retinal tissue damage was confined to the photocoagulated areas in most eyes and the loss of ganglion cells began when the occlusion persisted over 1 day. If the reproducibility is further increased, this will be a good animal model of retinal vein occlusion in albino rats.