J Korean Ophthalmol Soc.  1992 Sep;33(9):901-906.

Effect of Topical Betoptic(R) and Mikelan(R) on the Perfusion Pressure

• Yoo KW
• Whang CJ
• Lee JH
• Rho SH

Abstract

The effects of topical Betoptic(R) 0.5% and Mikelan(R) 2% on the ophthalmic artery blood pressure and perfusion pressure were investigated in 30 healthy subjects using ophthalmodynamometer and Goldmann applanation tonometer. The subjects were divided into two groups and each has 15 healthy subjects. In a randomized, double-blind study, one eye of each subject received one drop of Betoptic(R) 0.5% or Mikelan(R) 2%, and fellow eye was received a drop of placebo. Diastolic ophthalmic artery blood pressure (OABPd), systolic artery blood pressure (OPBPs), and intraocular pressure (lOP) were measured just before and 2 hours after the instillation of the drugs. Mean ophthalmic arery blood pressure (OABPm) was calculated as OABPm = OABPd + 1/3 (OABPs - OABPd) and the perfusion pressure (PP) was calculated as PP = OABPm - lOP. The perfusion pressure (pp) was Betoptic(R)-treated group was increased by 9%, and that of Mikelan(R)-treated group was increased by 13%, these increasement were statistically significant (Both group P<0.01).

Keyword

Betoptic(R) 0.5%; Mikelan(R) 2%; Ophthalmodynamometer; Perfusion

MeSH Terms

Arteries
Blood Pressure
Double-Blind Method
Intraocular Pressure
Ophthalmic Artery
Perfusion*