J Korean Ophthalmol Soc.  1992 Sep;33(9):885-891.

The Effect of Subconjunctival Injection of Liposome Encapsulated Cytarabine on Proliferation of Fibroblasts

• Seong GJ
• Hong YJ
• Park SJ

Abstract

To know the effect of subconjunctival injection of liposome encapsulated cytarabine on proliferation of conjunctival fibroblasts, the conjunctiva was isolated at 180 degrees from the injection site 3 days after subconjunctival injection of the normal saline (control), cytarabine, liposome encapsulated cytarabine, and 1 day after injection of cytarabine, and then those were inoculated in the culture media of fibroblasts. In the case of 3 days after injection of cytarabine, there was 49% and 42% inhibition of proliferation of conjunctival fibroblasts compared with the control respectively. Therefore, the authors concluded that the liposome encapsulated cytarabine is effective on inhibition of proliferation of conjunctival fibroblasts and reduces the frequencies of subconjunctival injection compared with the cytarabine itself.

Keyword

Cytarabine; Fibroblast; Liposome encapsulated cytarabine

MeSH Terms

Conjunctiva
Culture Media
Cytarabine*
Fibroblasts*
Liposomes*
Culture Media
Cytarabine
Liposomes