J Korean Ophthalmol Soc.  1989 Apr;30(2):261-266.

A Clinical Effect of Pilocarpine Gel(Pilogel(R) HS) in Glaucoma: Alternative Effect of 4% Pilocarpine Solution

• Moon JI
• Baek NH

Abstract

In order to research the clinical utility of Pilogel(R), we administered Pilogel(R) to 13 POAG(primary open angle glaucoma) patients once daily for four weeks and measured the degree of intraocular pressure reduction and accompanying side effects three days after; one week after; two weeks after; three weeks after and four weeks administration. 1. Administration of Pilogel(R) single dose at bed time produced the same effect of intraocular pressure reduction as that of 4% Pilocarpine eye drop four times a day. 2. Up to four weeks of daily administration of Pilogel(R) did not produced tachyphylaxis. 3. Degree of intraocular pressure reduction after administration of Pilogel(R) was maintained at the almost same level from days 3 up to 4 weeks. 4. The intraocular pressure reduction effect with pilogel(R) was maintained at the constant level for 18 hours following administration of it. 5. Once a day regimen of Pilogel(R) was proven to be more comfortable than the 4 times a day regimen of pilocarpine eye drop. And the side effect of Pilogel(R) was no greater than that of pilocarpine eye drop.

Keyword

pilogel(R); intraocular pressure; tachyphylaxis

MeSH Terms

Glaucoma*
Humans
Intraocular Pressure
Pilocarpine*
Tachyphylaxis
Pilocarpine