J Korean Pediatr Soc.  1980 Jul;23(7):521-526.

Effects of the Cyclophosphamide and 6-Mercaptopurine on the RES Function in Rats

• Hwang TJ
• Kim HC
• Sohn C
• Cho KH

Abstract

To study the effect of anticancer drugs on the RESFunction, cyclophosphamide and 6-mercaptopurine were intramuscularly injected and evaluated the reticuloendotherial phagocytic activity by the carbon clearence method in rats. Experimental groups were subdivided by the dosage, into the small and large dosage groups, and by the duration of treatment, into the 1, 3, 5 days and 8days (3 days cessation after 5 days treatment) groups. The results obtained were as follow. 1. Cyclophosphamide-treated groups showed the splenic atrophy which was in proportion to duration of treatment. RES phagocytic activities seemed to be slightly increased in large groups, but to be within normal ranges in ranges in small dosage groups, which were normalized in the 8 days groups. 2. 6-Mercaptopurine-treated groups didn't show the hepatic and splenic alterations significantly. RES phagocytic activities were variably changed as in triphagic curve fashion in both small and large dosage subgroups of 1, 3, 5 days treated groups, which were normalized in the 8 days groups.

MeSH Terms

6-Mercaptopurine*
Animals
Atrophy
Carbon
Cyclophosphamide*
Rats*
Reference Values
6-Mercaptopurine
Carbon
Cyclophosphamide