- A Case of Evans Syndrome, Successfully Treated with 6-Mercaptopurine
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Lyu CJ, Park KI, Kim KY
- KMID: 693026
- Yonsei Med J.
- 1986 Jun;27(2):147-151.
- doi: 10.3349/ymj.1986.27.2.147
A pediatric patient with combined primary thrombocytopenic purpura and acquired hemolytic anemia (Evans syndrome), whose condition did not respond to treatment with prednisolone, has enjoyed long-term remission following a period... -
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- Pancreatitis Induced by 6-mercaptopurine and 6-thioguanine in Childhood Acute Lymphoblastic Leukemia
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Yoon JH, Baek JS, Kim EK, Kang HJ, Shin HY, Ahn HS
- KMID: 1485158
- Korean J Hematol.
- 2008 Mar;43(1):53-57.
- doi: 10.5045/kjh.2008.43.1.53
Although pancreatitis is known as a common complication during the treatment of acute lymphoblastic leukemia, acute pancreatitis that's induced by 6-mercaptopurine or 6-thioguanine is very uncommon. We experienced the case... -
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- Effects of the Cyclophosphamide and 6-Mercaptopurine on the RES Function in Rats
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Hwang TJ, Kim HC, Sohn C, Cho KH
- KMID: 1946119
- J Korean Pediatr Soc.
- 1980 Jul;23(7):521-526.
To study the effect of anticancer drugs on the RESFunction, cyclophosphamide and 6-mercaptopurine were intramuscularly injected and evaluated the reticuloendotherial phagocytic activity by the carbon clearence method in rats. Experimental... -
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- Acute Pancreatitis Induced by Azathioprine and 6-mercaptopurine Proven by Single and Low Dose Challenge Testing in a Child with Crohn Disease
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Yi GC, Yoon KH, Hwang JB
- KMID: 2315351
- Pediatr Gastroenterol Hepatol Nutr.
- 2012 Dec;15(4):272-275.
We report here a case of drug-induced acute pancreatitis proved by elimination and single, low dose challenge test in a child with Crohn disease. A 14-year-old boy with moderate/severe Crohn... -
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- The Frequency and the Course of the Adverse Effects of Azathioprine/6-Mercaptopurine Treatment in Patients with Inflammatory Bowel Disease
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Cha JM, Kim HJ
- KMID: 1767534
- Korean J Gastroenterol.
- 2008 May;51(5):319-322.
No abstract available. -
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- A Case of Acral Erythema Induced by Etoposide
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Jeon EK, Kim YJ, Lee Y, Seo YJ, Park JK, Lee JH
- KMID: 2302096
- Korean J Dermatol.
- 2008 Mar;46(3):418-420.
Etoposide is a semi-synthetic podophyllotoxin that binds to microtubular proteins to inhibit cell division. It has been used extensively in the treatment of both solid and hematologic malignancies. Chemotherapy-induced acral... -
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- A Case of Gougerot-Blum Syndrome with Leukemia
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Myung KB, Kim HJ, Lee SN
- KMID: 1664749
- Korean J Dermatol.
- 1977 Dec;15(4):499-503.
Gougerost-Blum syndrome is a rare disease and characterized by lichenoid papules in association with purpuric lesions. So far as we know there has been no report of, in literatures, Gougerot-Blum... -
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- Severe recurrent nocturnal hypoglycemia during chemotherapy with 6-mercaptopurine in a child with acute lymphoblastic leukemia
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Cho EM, Moon JE, Lee SJ, Ko CW
- KMID: 2432275
- Ann Pediatr Endocrinol Metab.
- 2018 Dec;23(4):226-228.
- doi: 10.6065/apem.2018.23.4.226
Various endocrine dysfunctions occur during chemotherapy, including hypoglycemia. However, reports of hypoglycemia associated with 6-mercaptopurine (6-MP) are rare. Herein, we report an 8-year-old boy with severe symptomatic hypoglycemia likely due... -
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- The Effect of Milk on the Bioavailability of 6-mercaptopurine
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Park SK, Kim RJ, Hwang PH, Cho SC, Kim JS
- KMID: 1879515
- J Korean Pediatr Soc.
- 1994 Dec;37(12):1732-1737.
The purine antimetabolite 6-Mercaptopurine (6-MP) has been in clinical use for over 30 years and is still a widely used agent in the treatment of childhood acute lymphoblastic leukemia. The... -
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- Three Cases of Refractory Psoriasis Treated with Low-dose Azathioprine and Acitretin Combined Therapy
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Jang SH, Yun SJ, Lee JB, Kim SJ, Won YH, Lee SC
- KMID: 2246273
- Korean J Dermatol.
- 2014 Oct;52(10):735-740.
Azathioprine is an imidazole derivative of 6-mercaptopurine and is well known for its role in T and B lymphocyte inhibition. These properties have made it useful in the treatment of... -
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- Effect of Immunomodulators and Biologic Agents on Malignancy in Patients with Inflammatory Bowel Disease
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Kim JH, Kim JW
- KMID: 2392911
- Korean J Gastroenterol.
- 2017 Oct;70(4):162-168.
- doi: 10.4166/kjg.2017.70.4.162
Immunosuppressive agents and biological agents are widely used for therapy in patients with inflammatory bowel disease (IBD). However, these therapies may be associated with an increased risk of malignancy. There... -
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- Genetic Polymorphism of Thiopurine Methyltransferase in Children with Acute Lymphoblastic Leukemia
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Cho HG, Baek HJ, Han DK, Bae SY, Kook H, Hwang TJ
- KMID: 1483074
- Clin Pediatr Hematol Oncol.
- 2008 Apr;15(1):1-9.
Purpose: 6-mercaptopurine (6-MP) is a very important drug in pediatric patients for the maintenance treatment of acute lymphoblastic leukemia (ALL). 6-MP is catabolized by thiopurine methyltransferase (TPMT). TPMT activity, one... -
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- A Case of Oligodendroglioma after Treatment of Acute Lymphoblastic Leukemia in Childhood
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Shin SH, Chung BH, Bauer S, Lee JH, Lee KC
- KMID: 2049282
- Clin Pediatr Hematol Oncol.
- 2012 Oct;19(2):118-122.
Secondary brain tumors after cranial irradiation have been reported in survivors of childhood acute lymphoblastic leukemia (ALL). We report a case of secondary oligodendroglioma, occurring in a 19-year-old male, 12... -
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- The Safety and Efficacy of Azathioprine and 6-Mercaptopurine in the Treatment of Korean Patients with Crohn's Disease
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Lee HJ, Yang SK, Kim KJ, Choe JW, Yoon SM, Ye BD, Byeon JS, Myung SJ, Kim JH
- KMID: 2174114
- Intest Res.
- 2009 Jun;7(1):22-31.
BACKGROUND/AIMS: This study aimed to evaluate the adverse events and efficacy of azathioprine (AZA) and 6-mercaptopurine (6-MP) in Korean patients with Crohn's disease (CD). METHODS: We retrospectively analyzed 700 patients with... -
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- The Association between the Therapeutic Agent and the Compliance of the Patients with Inflammatory Bowel Diseases
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Kang YS, Kim SY, Jo MH, Kang HW, Lee JK, Lim YJ, Koh MS, Lee JH, Yang CH, Kim JH
- KMID: 1718062
- Korean J Gastroenterol.
- 2013 Jun;61(6):313-318.
- doi: 10.4166/kjg.2013.61.6.313
BACKGROUND/AIMS: Adherence of the patients with inflammatory bowel diseases is important to maintain the remission. However, the patients do not always keep their appointments for treatment. The aim of this... -
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- A Case of Acute Dilated Cardiomyopathy Caused by Coxsackie Virus B in a Patient with Crohn's Disease
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Kwon CI, Hong SP, Choi YJ, Hwang KH, Oh J, Kim KC, Hwang SG, Park PW, Rim KS
- KMID: 2304653
- Korean J Gastroenterol.
- 1999 Jul;34(1):125-130.
A 23-year-old man was admitted for watery diarrhea, abdominal pain and fever. He had received an operation for an anal fistula at a private clinic about 3 years ago. Recently,... -
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- Oral Maintenance Chemotherapy with 6-Mercaptopurine and Methotrexate in Patients with Acute Myeloid Leukemia Ineligible for Transplantation
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Choi YW, Jeong SH, Ahn MS, Lee HW, Kang SY, Choi JH, Park JS
- KMID: 2344173
- J Korean Med Sci.
- 2015 Oct;30(10):1416-1422.
- doi: 10.3346/jkms.2015.30.10.1416
For decades, maintenance chemotherapy has failed to improve the cure rate or prolong the survival of patients with acute myeloid leukemia (AML), other than those with acute promyelocytic leukemia. Immediately... -
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- APEX1 Polymorphism and Mercaptopurine-Related Early Onset Neutropenia in Pediatric Acute Lymphoblastic Leukemia
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Kim H, Seo H, Park Y, Min BJ, Seo ME, Park KD, Shin HY, Kim JH, Kang HJ
- KMID: 2417871
- Cancer Res Treat.
- 2018 Jul;50(3):823-834.
- doi: 10.4143/crt.2017.351
PURPOSE: Mercaptopurine (MP) is one of the main chemotherapeutics for acute lymphoblastic leukemia (ALL). To improve treatment outcomes, constant MP dose titration is essential to maintain steady drug exposure, while... -
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- The Frequency and the Course of the Adverse Effects of Azathioprine/6-Mercaptopurine Treatment in Patients with Inflammatory Bowel Disease
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Kim JH, Cheon JH, Kim WH
- KMID: 1767529
- Korean J Gastroenterol.
- 2008 May;51(5):291-297.
BACKGROUND/AIMS: This study was to evaluate the frequency and the course of the adverse effects of AZA/6-MP in Korean patients with inflammatory bowel disease (IBD). METHODS: Medical records of the... -
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- 6-Thioguanine-Induced Hepatic Sinusoidal Obstruction Syndrome in a Leukemic Child with TPMT Heterozygote
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Kwon YJ, Yoon JH, Park JA, Bang JS, Park BK, Choi JI, Kong SY, Park HJ
- KMID: 2049280
- Clin Pediatr Hematol Oncol.
- 2012 Oct;19(2):109-113.
Hepatic sinusoidal obstruction syndrome (hSOS) can be developed as a common complication after hematopoietic stem cell transplantation (HSCT), and rarely after 6-thioguanine-based chemotherapy without HSCT. A four-year-old boy with heterozygotic... -
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