J Korean Radiol Soc.  1997 Jul;37(1):51-57.

Intratumoral Vascularity of Experimentally Induced VX2 Carcinoma: Comparison of Power Doppler Sonography and Microangiography

• Park KS
• Won HJ
• Seo JB
• Kim TK
• Han JK
• Choi BI

Abstract

PURPOSE
To evaluate the usefulness and limitations of power Doppler sonography in determining the tumor vascularity.
MATERIALS AND METHODS
Power Doppler sonography was performed on VX2 carcinomas present in rabbit thighs, and the findings were compared with those of microangiography in an almost identical plane. Tumor vascularity was qualitatively analysed on the basis of tumor vessel distribution and density, and the presence of thick and thin vesels ; for a comparison of tumor vascularity as seen on microangiography, tumor blood flow signals shown by power Doppler sonography were graded 3, 2, 1, 0. For quantitative analysis, a comparison was made of the percentage of tumor area occupied by vessels, as shown in each study. Data analysis utilized the Wilcoxon signed-rank test and Spearman correlation test.
RESULTS
Mean tumor vascularity scores, as seen on power Doppler sonography and relating to tumor vessel distribution and density, and the presence of thick and thin vessels, were 2.87, 2.73, 2.93 and 2.73, respectively. The means and medians of the percentages of tumor area occupied by vessels were 22.7% & 23.5% and 36.4% & 34.7% on microangiography and power Doppler sonography, respectively. Thus, there was good correlation between these two modes.
CONCLUSION
Power doppler sonography could demonstrate the tumor vascularity on microangiography relatively well but tend to overestimate it.

Keyword

Neoplasms, experimental; Neoplasms, blood supply; Ultrasound (US), Doppler studies

MeSH Terms

Neoplasms, Experimental
Statistics as Topic
Thigh