J Korean Soc Emerg Med.  2005 Jun;16(3):387-389.

A Case of Thrombotic Thrombocytopenic Purpura

• Hong SW
• Min JH
• Do HS
• Chung SP
• Kim SW
• Yoo IS

Abstract

A thrombotic thrombocytopenic purpura (TTP) is a disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, neurologic symptoms, fever, and impairment of renal function, which are thought to be due to endothelial cell injury, platelet activation, and subsequent formation of thrombi in the microcirculation. The most common neurologic symptoms are alteration of mental status, headache, coma, focal weakness, aphagia, dysarthria, seizure, and visual changes. Avoiding platelet transfusions, which can exacerbate microvascular thrombosis, is prudent. We experienced a case of TTP which was aggravated after platelet transfusion. We report that case with a literature review.

Keyword

Purpura; Thrombotic thrombocytopenic; Neurologic manifestations; Platelet transfusion

MeSH Terms

Anemia, Hemolytic
Coma
Dysarthria
Endothelial Cells
Fever
Headache
Microcirculation
Neurologic Manifestations
Platelet Activation
Platelet Transfusion
Purpura
Purpura, Thrombotic Thrombocytopenic*
Seizures
Thrombocytopenia
Thrombosis