Retrospective Study of Clinical Features and Courses of Raynaud's Phenomenon

Yoo, Ki Eun; Lee, Kyung Bok; Kim, Dong Ik

Abstract

PURPOSE: Raynaud's phenomenon is characterized by recurrent episodes of arterial vasospasm of the digits upon exposure to cold, and this can occur alone or in association with other underlying conditions. The aim of this study was to investigate the clinical course of Raynaud's phenomenon and the effects of treatment. METHOD: Between September 1994 and December 2004, 69 patients with Raynaud's phenomenon were retrospectively evaluated. The symptoms of the patients and the results of photoplethysmography were reviewed before and after medical treatment. RESULT: The mean age of the patients was 47.4 years and 33 patients (47.8%) were in their 30s and 40s. Thirty seven patients (53.6%) were male and 32 patients (46.4%) were female. Twelve patients (17.4%) had combined disease and the majority of the total patients (n=58, 84%) presented with bilateral lesions. After treating with aspirin, cilostazol, PGI2 and PGE1, the symptoms improved in 27 cases (39.1%) and the photoplethysmographic findings improved in 20 cases (45.5%). However, there was no association between the period of treatment and the clinical results or the results of performing photoplethysmography. CONCLUSION: The majority of patients with Raynauds phenomenon develop bilateral symptoms without the presence of any underlying diseases. Antiplatelet agents and vasodilator drugs can have a positive effect on the management of Raynaud's phenomenon.