Korean Circ J.  2001 Nov;31(11):1194-1199. 10.4070/kcj.2001.31.11.1194.

Changes of Heart Rate Variability in Patients with Postmenopausal Syndrome after Hormonal Replacement Treatment

• Oh JH
• Kim JS
• Yoon BK
• Lee SY
• Kim JK
• Lee SC
• Gwon HC
• Park SW
• Kim DK
• Lee SH
• Hong KP
• Park JE
• Seo JD
• Lee WR

• KMID: 1938938
• DOI: http://doi.org/10.4070/kcj.2001.31.11.1194

Abstract

BACKGROUND AND OBJECTIVES
Climacteric women often suffer from vasomotor symptoms. These symptoms are thought to be related to an imbalance of autonomic control of the cardiovascular system and are effectively controlled with hormonal replacement therapy. Heart rate variability (HRV) reflects the autonomic integration of the cardiovascular system. In this study, we attempted to compare the HRV indices of postmenopausal women before and after hormonal replacement therapy.
SUBJECTS AND METHODS
Eighteen patients with postmenopausal syndrome (mean age:53+/-4 years) received estrogen and/or progesterone replacement therapy. They underwent 24-hour ambulatory electrocardiographic monitoring at baseline and after the early period of therapy (mean:112+/-19 days) and eleven patients underwent the examination after the later period of therapy (mean 213+/-23 days). HRV was analyzed over a full 24-hour period, using time and frequency domain parameters.
RESULTS
No statistically significant HRV change was observed during the early period of therapy. However, during the later therpy period , HRV indices such as rMSSD[from 27.6 to 31.3 (msec)], HF[from 4.8 to 5.05 ln (ms2)], LF/HF ratio (from 1.17 to 1.12) were significantly changed (p value<0.05).
CONCLUSION
HRV was significantly changed in postmenopausal women during the later period of hormonal replacement therapy.

Keyword

Heart rate; Menopause; Hormone replacement therapy

MeSH Terms

Cardiovascular System
Climacteric
Electrocardiography, Ambulatory
Estrogens
Female
Heart Rate*
Heart*
Hormone Replacement Therapy
Humans
Menopause
Progesterone
Estrogens
Progesterone