Korean Circ J.  2001 Dec;31(12):1305-1310. 10.4070/kcj.2001.31.12.1305.

Efficacy of Amiodarone in Tachycardia Induced Cardiomyopathy due to Non-Valvular Atrial Fibrillation

• Yom HJ
• Park SH
• Jeon SH
• Chang JE

• KMID: 1938921
• DOI: http://doi.org/10.4070/kcj.2001.31.12.1305

Abstract

BACKGROUND AND OBJECTIVES
Drug therapy to treat atrial fibrillation has been achieved unsatisfactory results due to the frequent failure to maintain a sinus rhythm as well as the occurrence of adverse side effects. This study investigated the efficacy of amiodarone for the treatment of tachycardia-induced cardiomyopathy due to non-valvular atrial fibrillation.
SUBJECTS AND METHODS
We treated twenty-seven patients with tachycardia-induced cardiomyopathy due to non-valvular atrial fibrillation with amiodarone in order to convert to and maintain the sinus rhythm. We followed up and compared the functional status, electrocardiography and parameters of echocardiography before and after treatment with amiodarone.
RESULTS
Patients treated with amiodarone showed cardiac functional improvement based on New York Heart Association classification. Eighteen patients (66.7%) out of the total 27 converted to sinus rhythm. The pulse rate decreased from 109.0+/-34 bpm (beats per min) before the administration of amiodarone to 70.3+/-13.0 bpm after medication. The size of the left atrium decreased from 50.7+/-6.7 (mm) to 46.9+/-5.6 (mm). The ejection fraction (EF) improved from 36.2+/-14.9 (%) to 51.2+/-17.7 (%).
CONCLUSION
Amiodarone is effective in the conversion to sinus rhythm as well as ventricular rate control in patients with atrial fibrillation induced cardiomyopathy. The cardiac functional status and the echocardiographic parameters of left ventricular function in patients with tachycardia-induced cardiomyopathy due to atrial fibrillation improved with amiodarone therapy.

Keyword

Atrial fibrillation; Tachycardia; Myocardial diseases; Amiodarone; Echocardiography

MeSH Terms

Amiodarone*
Atrial Fibrillation*
Cardiomyopathies*
Classification
Drug Therapy
Echocardiography
Electrocardiography
Heart
Heart Atria
Heart Rate
Humans
Tachycardia*
Ventricular Function, Left
Amiodarone