Korean Circ J.  1997 Jun;27(6):600-607. 10.4070/kcj.1997.27.6.600.

Change of Complex and Periodic Heart Rate Dynamics with Change of Pulmonary Artery Pressure in Infants with Ventricular Septal Defect

• Yum MK
• Kim NS
• Woo HO

• KMID: 1938620
• DOI: http://doi.org/10.4070/kcj.1997.27.6.600

Abstract

BACKGROUND
We studied how periodic and complex heart rate dynamic changes as pulmonary artery pressure increases in 32 infants with ventricular septal defet. In addition, we tested the possibility that the dynamical changes can be used to noninvasively predict the pulmonary artery pressure.
METHODS
During cardiac catherterization, mean pulmonary artery pressure was measured and, at the same time, 5minute segments of continous electrocardiographic recording was stored. High-(>0.15 hertz) and low-(0.03-0.15 hertz) frequency components of heart rate variability were computed using spectral analysis. Yhe overall complexity of heart rate time series was quantified by its approximate entropy. RESULT: Pulmonary hypertensive infants(mean pulmonary artery pressure>20mmHg, n=17) had significantly lower low-(p<0.05)and high-(p<0.05) frequency power and lower approximate entropy(p<0.0001) than pulmonary normotensive infants(mean pulmonary artery pressure20mmHg, n=15). The mean pulmonary artery pressure was significantly correlated not with the spectral powers but with approximate entropy(=-0.51, P=0.0001).
Conclusion
It can be concluded that, in infants, pulmonary hypertension induced by left-to-right shunt lesions suppress both periodic and complex heart rate oscillation and that mean pulmonary artety pressure can be predicted by calculating approximate entropy of heart trate variability.

Keyword

Pulmonary hypertension; Heart Rate complexity; Approximate entropy

MeSH Terms

Electrocardiography
Entropy
Heart Rate*
Heart Septal Defects, Ventricular*
Heart*
Humans
Hypertension, Pulmonary
Infant*
Pulmonary Artery*