Korean Circ J.  1983 Dec;13(2):343-348. 10.4070/kcj.1983.13.2.343.

Pathologic Changes of Peripheral Pulmonary Arteries in Ventricular Septal Defect with Pulmonary Hypertension

• Lee SK
• Hong CH
• Sul JH
• Chin DS
• Yun DJ
• Park CI
• Cho BK

• KMID: 2093161
• DOI: http://doi.org/10.4070/kcj.1983.13.2.343

Abstract

Twelve patients with ventricular septal defect with pulmonary hypertension underwent lung biopsy to assess pulmonary obstructive vascular disease at the time of open heart surgery. According to the Heath and Edwards classification in grading of Pulmonary obstructive vasculr disease, there are eleven cases in grade 1 and one case in grade 3. Thickness of media was measured. It was expressed as percentage of medial thickness to outer diameter of artery. The medial thickness was correlated proportionally with elevation of pulmonary arterial pressure and pulmonary vascular resistance to systemic resistance ratio. In tolazoline test performed in 4 cases, one patients who had pulmonary obstructive vascular disease, had no change of pulmonary vascular resistance to systemic vascular resistance after intravenous injection of tolazoline during cardiac catheterization, but Rp/Rs of three cases was decreased significantly.

Keyword

Lung biopsy; Pulmonary hypertension; Ventricular septal defect

MeSH Terms

Arterial Pressure
Arteries
Biopsy
Cardiac Catheterization
Cardiac Catheters
Classification
Heart Septal Defects, Ventricular*
Humans
Hypertension, Pulmonary*
Injections, Intravenous
Lung
Pulmonary Artery*
Thoracic Surgery
Tolazoline
Vascular Diseases
Vascular Resistance
Tolazoline