Korean J Anesthesiol.  2007 Mar;52(3):269-274. 10.4097/kjae.2007.52.3.269.

Evaluation of Effect-site Concentration of Remifentanil for Blunting Hemodynamic Responses to Endotracheal Intubation during Total Intravenous Anesthesia using Propofol

• Lee JH
• Kim SI
• Ok SY
• Kim SC

• KMID: 1937588
• DOI: http://doi.org/10.4097/kjae.2007.52.3.269

Abstract

BACKGROUND
The present study was undertaken to determine the effect-site concentration of remifentanil for blunting hemodynamic responses to tracheal intubation during total intravenous anesthesia (TIVA) using propofol.
METHODS
In this prospective, randomized, double-blind study, a total of 126 patients, aged 18-60 (ASA I or II), having undergone elective surgery under TIVA using propofol were investigated. Anesthesia was induced using propofol (target effect-site concentration 4microgram/ml) and rocuronium (0.9 mg/kg). Remifentanil was infused at target effect-site concentrations of 0, 2, 4, 6 ng/ml: groups R1, R2, R3 and R4, respectively. The systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and heart rate (HR) were measured pre-induction, and before and after tracheal intubation.
RESULTS
After intubation, the SAP, DAP and HR increased significantly (P < 0.05) in all groups compared to the pre-intubation values. Compared with pre-induction values, the SAP and DAP in groups R1 and R2 increased significantly after intubation (P < 0.05), but those in group R3 remained constant until 1 min after intubation. The SAP and DAP in group 4 however, decreased significantly (P < 0.05) for 3 min after intubation. The HR increased significantly after intubation in groups R1, R2 and R3 compared to the values before intubation (P < 0.05), but that in group R4 being remained constant.
CONCLUSIONS
We suggest that the optimal target effect-site concentrations of remifentanil for blunting hemodynamic responses to tracheal intubation were 4 or 6 ng/ml during TIVA using propofol.

Keyword

effect-site concentration; hemodynamic response; propofol; remifentanil; total intravenous anesthesia; tracheal intubation

MeSH Terms

Anesthesia
Anesthesia, Intravenous*
Arterial Pressure
Double-Blind Method
Heart Rate
Hemodynamics*
Humans
Intubation
Intubation, Intratracheal*
Propofol*
Prospective Studies
Propofol