Korean J Anesthesiol.  2005 Nov;49(5):667-670. 10.4097/kjae.2005.49.5.667.

The Efficacy and Incidence of Side Effects in Patient Controlled Analgesia Using Hydromorphone

• Oh AY
• Park YO
• Jeon YT
• Jung MW
• Lee HK
• Oh YS

• KMID: 1936824
• DOI: http://doi.org/10.4097/kjae.2005.49.5.667

Abstract

BACKGROUND: Hydromorphone, a derivative of morphine, has the same actions and uses as morphine, has about eight times more potency on a milligram basis. Hydromorphone is used for the relief of moderate to severe pain. There has been no report in Korea on patient controlled analgesia (PCA) using hydromorphone. Here, the efficacy and incidence of side effects of PCA, with hydromorphone, were investigated.
METHODS
68 patients scheduled for spinal, urological, gynecological and general surgery were enrolled. Patients received standardized general anesthesia, with the PCA initiated at the end of surgery. Parameters for PCA were a 0.1 mg bolus and 0.05 mg/hr infusion of hydromorphone, with a 10 min lockout interval. A verbal rating scale (1: none, 2: very mild, 3: mild, 4: moderate, 5: severe) of pain, nausea (mild, moderate, severe), vomiting, dizziness and somnolence were assessed at 6, 12, 24 hr postoperatively. The amount of hydromorphone used and the requirements for symptomatic relief were also recorded.
RESULTS
The mean pain scores were 3.5+/-0.8, 2.9+/-0.8 and 2.5+/-0.7, and the amounts of hydromorphone delivered were 1.0+/-0.1, 1.8+/-1.0 and 2.7+/-1.3 mg, 6, 12 and 24 hr postoperatively, respectively. The incidence of nausea, vomiting, dizziness and somnolence were 17.6, 4.4, 8.8 and 1.5%, respectively.
CONCLUSIONS
Intravenous PCA, with hydromorphone, was effective in controlling postoperative pain, with fewer eide effects than morphine, as reported in the literature.

Keyword

hydromorphone; nausea; patient controlled analgesia

MeSH Terms

Analgesia, Patient-Controlled*
Anesthesia, General
Dizziness
Humans
Hydromorphone*
Incidence*
Korea
Morphine
Nausea
Pain, Postoperative
Passive Cutaneous Anaphylaxis
Vomiting
Hydromorphone
Morphine