Korean J Anesthesiol.  1988 Dec;21(6):903-909. 10.4097/kjae.1988.21.6.903.

Osmolalities of Commercially Supplied Drugs Used in Anesthesia

• Lee SK
• Kim HM
• Kim GD

• KMID: 1933072
• DOI: http://doi.org/10.4097/kjae.1988.21.6.903

Abstract

To investigate the osmolality of commercially supplied drugs used in anesthesia, the authors measured the osmolality of a total of 62 drugs with osmometer using the principle of freezing point depression. The osmolality range of drugs observed was 0-12,478 mOsm/kg water. The drugs of osmolality between 240 and 340 mOsm/kg water were 21(34%). Hypertonic drugs(<240 mOsm/kg water) were 18(29%) indicating two-thirds of the drugs were hypo-or hypertonic. Therefore, it is recommended that extreme hypo-or hypertonic drugs should be administered cautiously especially when they are administered rapidly and massively in order to prevent hemolysis or cell shrinkage.

Keyword

Osmolality; Drugs

MeSH Terms

Anesthesia*
Depression
Freezing
Hemolysis
Osmolar Concentration*
Water
Water