Korean J Anesthesiol.  1983 Jun;16(2):91-98.

Circulatory Response to Laryngoscopy and Tracheal Intubation with or without Prior Injection of Meperidine and Diazepam

• Oh KM
• Lee CH

Abstract

Direct laryngoscopy and endotracheal intubation cause increased arterial blood pressure and heart rates. These cirulatory effects are due to mechanical stimulation of the laryngopharynx and traches via efferent cervical sympathestic fibers. And various cardiac arrhythmias, even-cardiac arrest may occur by stimulation of the vague nerve during intubation. The present study observed the ECG and circulatory changes following i.v. injection of meperidine, 50 mg, and diazepam, 10mg, as primary i.v. anesthetic agents, for the purpose of the prevention of circulatory stimulation before laryngoscopy and tracheal intubation. This study was undertaken on eight-eight, ASA class l-ll patients of either sex undergoing elective surgical procedures in the Department of Anesthesiology at Ewha Womans University hospital. The results were as follows: 1) The increases of systolic blood pressure following intubation were markedly reduced in the pre-treated groups for both normotensive and hypertensive individuals. 2) Heart rates following intubation were markedly increased in all groups. 3) Transient abnormal findings in the ECG appeared in sixty-nine cases(78.4%) following intubation and the majority showed sinus tachycardia. 4) pH, PaCO2, and PaO2 values were within normal range following intubation in all groups.

MeSH Terms

Anesthesiology
Anesthetics
Arrhythmias, Cardiac
Arterial Pressure
Blood Pressure
Diazepam*
Electrocardiography
Female
Heart Rate
Humans
Hydrogen-Ion Concentration
Hypopharynx
Intubation*
Intubation, Intratracheal
Laryngoscopy*
Meperidine*
Reference Values
Surgical Procedures, Elective
Tachycardia, Sinus
Anesthetics
Diazepam
Meperidine