Korean J Anesthesiol.  1968 Jan;1(1):37-41.

The Clinical Observation of Patients infused with Laetated Ringer Solution during Surgery

• Kwon CJ

Abstract

Our own preliminary experiences with the use of lactated Ringer solution during major surgery have been reported. We used 10cc/kg/hr in 40 patients throughout the operative period, and compared them with a control group of 30. Observations were made for the following; RBC, Hct, Hgb, electrolytes, and urine output. There were no significant differences in blood constituents and electrolytes between the two groups, but considerable increase in urinary outupt was noticed in the experimental group during 24 hour post-operative period. Blood transfusion had been done to replace blood loss and the experimental group had considerable reduction of transfused blood volume during surgery. We accept and produce evidence for the concept, pronounced by Epstein, that decrease in functional rextra-cellular fluid is a major determinant to sodium excretion. A major limitation of post-operative sodium excretion seemed to be the acute contraction of the functional extracelluar fluid incurred by surgery. If the losses of extracellular fluid were replaced during the operation, the phenomenon of sodium retention, was not seen. Neither normal saline nor 5% dextrose adequately replace the extracellular loss and kidneys do not eliminate excess water in this way. Lactated Ringer solution prevents acidosis and concomittant retention of water and sodium, and at the same time, sodium is adequately eliminated. It appears that this is an advance in managing fluid and electrolyte balance during surgery.

MeSH Terms

Acidosis
Blood Transfusion
Blood Volume
Electrolytes
Extracellular Fluid
Glucose
Humans
Kidney
Sodium
Water
Water-Electrolyte Balance
Electrolytes
Glucose
Sodium
Water