Korean J Blood Transfus.  1996 Jun;7(1):71-76.

A Severe Case of Hemolytic Disease of the Newborn due to Anti-M Antibody

• Han KS
• Choi JH
• Kim HS
• Whang DH

Abstract

Anti-M antibody is usually a naturally occurring antibody reacting optimally 4 degrees C and is not considered to be clinically significant. Rarely has anti-M been implicated in hemolytic disease of the newborn(HDN) and the true incidence of HDN due to anti-M has not been well delineated. Authors report the second case of hemolytic disease of the newborn due to anti-M in Korea. A 3-days old baby boy was admitted due to jaundice and severe anemia which were developed at birth. The blood type of his mother was A, CcDEe, Ns, while the blood type of the infant of was A, CcDEe, MNs. The mother's serum had anti-M which wits strongnly positive in room temperature and albumin phase. The reaction was only weakly positive in the antiglobulin phase. Direct antiglobulin test of baby's red cells was negative, while the serum was weakly positive in polyethylene glycol-Coombs test. The antibody was found to be partially IgG through the treatment with dithiothreitol. After an exchange transfusion and phototherapy, the anemia and jaundice were corrected and and the patient discharged at the age of 16.

MeSH Terms

Anemia
Coombs Test
Dithiothreitol
Humans
Immunoglobulin G
Incidence
Infant
Infant, Newborn*
Jaundice
Korea
Male
Mothers
Parturition
Phototherapy
Polyethylene
Dithiothreitol
Immunoglobulin G
Polyethylene