Korean J Leg Med.  2005 Oct;29(2):196-203.

Milk aspiration as a Result of Hypotonic-hyporesponsive Episodes after DTaP and Polio Co-immunization

• Kim EN
• Maeng YH
• Kang HW

Abstract

We analyzed autopsy findings of 5 neonates and infants who suddenly died after DTaP and Polio Coimmunization. Microscopically, there were multifocal small amounts of pinkish amorphous materials within the alveolar spaces with marked proliferation of alveolar macrophages. Immunohistochemical stain using anti-human alpha-lactalbumin shows intense staining to these foreign materials. We concluded that milk aspiration and asphyxia may play an important role in course of death after DTaP and Polio Co-immunization and assumed that hypotonic-hyporesponsive episodes as an adverse events of immunization could be a preceding cause of milk aspiration. Education of parents about the risk of milk aspiration after immunization should be included in guideline.

Keyword

milk aspiration; DTaP; Polio; hypotonic-hyporesponsive

MeSH Terms

Asphyxia
Autopsy
Education
Humans
Immunization
Infant
Infant, Newborn
Lactalbumin
Macrophages, Alveolar
Milk*
Parents
Poliomyelitis*
Lactalbumin