Korean J Med.  2004 Nov;67(Suppl 3):S871-S875.

A case of metastatic malignant pheochromocytoma response to high dose 131I-MIBG treatment after surgery

• Lee SW
• Kim JG
• Ha SW
• Ahn BC
• Lee JT
• Kim BW
• Kim BW

Abstract

Approximately 10% of pheochromocytomas are malignant and its major criteria are tumor invasion of capsular blood vessel as well as metastatic invasion of other tissues. It is general rule that all resectable masses have to be removed surgically. However, there is no definite treatment modality about unresectable masses or microinvasive lesions. We experienced a case of 45 year-old male patient who was referred to our hospital for treatment of hypertension and headache. The plasma and urine catecholamine were increased above normal values and its metabolites also were increased. 131I-metaiodobenzylguanidine (MIBG) scan showed right adrenal mass and metastatic lesion of left iliac bone. This lesion was consistent with findings of the abdomen computed tomography (CT) and electron beam tomography (EBT) scan. We diagnosed this case as malignant pheochromocytoma. We removed primary tumor mass by wide excision and treated this patient with high dose 131I-MIBG. We report this case who shows good response to the high dose 131I-MIBG after surgery.

Keyword

Malingnant pheochromocytoma; Neoplasm metastasis; 3-Iodobenzylguanidine

MeSH Terms

3-Iodobenzylguanidine
Abdomen
Blood Vessels
Headache
Humans
Hypertension
Male
Middle Aged
Neoplasm Metastasis
Pheochromocytoma*
Plasma
Reference Values
Tomography, X-Ray Computed
3-Iodobenzylguanidine