Korean J Obstet Gynecol.
1997 May;40(5):965-972.
Expression of Transforming Growth Factor-beta1, beta2 by ImmunohistochemicalStaining METHOD: Comparison in Normal Pregnancy, Extopic Pregnancy, and Missed Abortion
- Affiliations
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- 1Department of Obstetrics and Gynecology, School of Medicine, Hanyang University, Seoul, Korea.
- 2Department of Pathology, School of Medicine, Hanyang University, Seoul, Korea.
Abstract
OBJECTIVES
This study have demonstrated that transforming growth factor TGF-beta s(TGF-beta 1 and TGF beta 2) may play an important role in implantation and also to determinethe defferences of in the decidua and placenta between normal pregnancy, ectopic pregnancy, and missedabortion.
METHODS
We have studied the expression of TGF-beta 1 and TGF-beta 2 byimmunohistochemical staining method in the decidua trophoblasts of normal early pregnancy, ectopicpregnancy, and missed abortion.
RESULTS
In the epithelial cells and decidua, TFG-beta 1 was moderately expressed in thenormal pregnancy and weakly expressed in the ectopic pregnancy. But TGF-beta 1 was notexpressed in missed abortion. In contrast, the epithelial expression of TGF-beta 2 was moderatelyin all groups and there are no differences among the groups. And in the decidua, TFG-beta 2 wasmoderately expressed in the normal pregnancy and missed abortion and was weakly expressed in theectopic pregnancy. In the trophoblasts, TFG-beta 1 was weakly expressed in all groups andTGF-beta 2 was moderately expressed in all groups that are no differences among the groups.
CONCLUSIONS
These findings suggest that TGF-beta 2 may have an important role in deciduaduring pregnancy, especially normal pregnancy. These could indicate that the presence oftroplablast and/or hormonal milieu of normal pregnancy resulted in the expression of TGF-beta s,particularly TGF-beta 1.
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