Korean J Obstet Gynecol.  1997 Sep;40(9):1829-1834.

Expression of Transforming Growth Factor-beta1 , beta2 by Immunohistochemical Staining method: In Human Endometrium through the Menstrual Cycle

• Hwang JH
• Hwang YY
• Jang SJ

Abstract

OBJECTIVES
The purpose of this study was to determine the differences of expression of TGF-betaS(TGF-beta1 and TGF-beta2) in the human proliferative endometrium, secretory endometrium, and the decidua during early pregnancy. And we also have studied the endometrial expression of TGF-beta1 and TGF-beta2 in the menopause and compared that to the expression in the endometrium and decidua.
METHODS
We have studied the expression of TGF-beta1 and TGF-beta2 by immunohistochemical staining method in the proliferative endometrium, secretory endometrium, decidua during early pregnancy, and menopausal endometrium.
RESULTS
In the epithelial cells, TGF-beta1 was moderately expressed in the secretory phase and was weakly expressed in the proliferative phase and menopause. In the stromal cells, TGF-beta1 was not expressed in the whole menstrual phase and menopause. And in the epithelial cells, TGF-beta2 was moderately expressed in the proliferative phase, secretory phase, and menopause. In the stromal cells, TGF-beta2 was not expressed in the whole menstrual phase and menopause. Especially, TGF-beta1 and TGF-beta2 were markedly expressed in the decidua during early pregnancy compared to the expression in the proliferative, secretory endometrium, and menopausal endometrium.
CONCLUSIONS
These findings suggest that TGF-beta1 may have an important role in the epithelial cells during the secretory phase, not stromal cells. And TGF-beta1 and TGF-beta2 may have a paracrine and autocrine role in the decidua/trophoblast interaction during pregnancy , especially in the normal pregnancy.

Keyword

Transforming growth factor-beta; Immnunohistochemical staining; Decidua

MeSH Terms

Decidua
Endometrium*
Epithelial Cells
Female
Humans*
Menopause
Menstrual Cycle*
Pregnancy
Stromal Cells
Transforming Growth Factor beta1
Transforming Growth Factor beta2
Transforming Growth Factor beta1
Transforming Growth Factor beta2