Arch Plast Surg.  2012 Jan;39(1):51-54. 10.5999/aps.2012.39.1.51.

Case Reports of Adipose-derived Stem Cell Therapy for Nasal Skin Necrosis after Filler Injection

• Sung HM
• Suh IS
• Lee HB
• Tak KS
• Moon KM
• Jung MS

• KMID: 1922787
• DOI: http://doi.org/10.5999/aps.2012.39.1.51

Abstract

With the gradual increase of cases using fillers, cases of patients treated by non-medical professionals or inexperienced physicians resulting in complications are also increasing. We herein report 2 patients who experienced acute complications after receiving filler injections and were successfully treated with adipose-derived stem cell (ADSCs) therapy. Case 1 was a 23-year-old female patient who received a filler (Restylane) injection in her forehead, glabella, and nose by a non-medical professional. The day after her injection, inflammation was observed with a 3x3 cm skin necrosis. Case 2 was a 30-year-old woman who received a filler injection of hyaluronic acid gel (Juvederm) on her nasal dorsum and tip at a private clinic. She developed erythema and swelling in the filler-injected area A solution containing ADSCs harvested from each patient's abdominal subcutaneous tissue was injected into the lesion at the subcutaneous and dermis levels. The wounds healed without additional treatment. With continuous follow-up, both patients experienced only fine linear scars 6 months postoperatively. By using adipose-derived stem cells, we successfully treated the acute complications of skin necrosis after the filler injection, resulting in much less scarring, and more satisfactory results were achieved not only in wound healing, but also in esthetics.

Keyword

Hyaluronic acid; Humans; Mesenchymal stem cell transplantation; Necrosis

MeSH Terms

Adult
Cicatrix
Dermis
Erythema
Esthetics
Female
Follow-Up Studies
Forehead
Humans
Hyaluronic Acid
Inflammation
Mesenchymal Stem Cell Transplantation
Necrosis
Nose
Skin
Stem Cells
Subcutaneous Tissue
Wound Healing
Young Adult
Hyaluronic Acid