Korean J Otolaryngol-Head Neck Surg.  1997 Dec;40(12):1752-1756.

Serum Immunoglobulins in Childrens with Recurrent Sinusitis

• Kim HK
• Kim HH
• Chung HR

Abstract

BACKGROUND: Sinusitis is a common and frequently recurrent illness in children. Respiratory allergy has been recognized as a major factor that predisposes children to recurrent and chronic sinusitis. Another important causative factors of recurrent sinusitis in children is immunodeficiency diseases. Among them, humoral immunodeficient disease especially is associated with recurrent sinusitis. Most common immune defect in recurrent sinusitis is immunoglobulin deficiency.
OBJECTIVES
The aim of this study is to obtain a quantitative data of serum immunoglobulins in children with recurrent sinusitis, to investigate a relationship between recurrent sinusitis and immunoglobulin deficiency.
MATERIALS AND METHODS
30 childrens were selected who had been diagnosed as recurrent sinusitis at Nowon Eulji hospital in 1996. The serum immunoglobulins were evaluated by Latex agglutination immunoassay and ELISA.
RESULTS
The serum IgG was within normal limits and IgA deficiency appeared in 1 patient but serum IgM appeared higher than normal value over 3 years patients. The serum IgG subclass deficiency appeared in 3 patients for IgG(1), 7 patients for IgG(2), 14 patients for IgG(3), 10 patients for IgG(4). The combined serum IgG subclass deficiency appeared in 4 patients for IgG(2) and IgG(3), 1 patient for IgG(2) and IgG(4), 4 patient for IgG(3) and IgG(4), 1 patient for IgG(1) and IgG(2) and IgG(3).
CONCLUSION
Immunoglobulin deficiency is approved to be closely associated with recurrent sinusitis in children.

Keyword

Recurrent sinusitis; Serum immunoglobulin; Immunodeficiency

MeSH Terms

Agglutination
Child*
Enzyme-Linked Immunosorbent Assay
Humans
Hypersensitivity
IgA Deficiency
Immunoassay
Immunoglobulin G
Immunoglobulin M
Immunoglobulins*
Latex
Reference Values
Sinusitis*
Immunoglobulin G
Immunoglobulin M
Immunoglobulins
Latex