Korean J Physiol Pharmacol.
2000 Aug;4(4):301-309.
Effects of prostaglandin F2alpha on membrane potentials and K+ currents in rabbit middle cerebral arterial cells
- Affiliations
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- 1Department of Physiology and Biophysics, College of Medicine, Inje University, 633-165 Gaegeum-dong, Busanjin-gu, Busan, South Korea.
Abstract
- The purpose of our investigation was to examine the effects of
prostaglandin F2alpha (PGF2alpha) on membrane potentials,
Ca2+-activated K+ (KCa) channels, and delayed rectifier K+ (KV)
channels using the patch-clamp technique in single rabbit middle
cerebral arterial smooth muscle cells. PGF2alpha significantly
hyperpolarized membrane potentials and increased outward whole-cell K+
currents. PGF2alpha increased open-state probability of KCa channels
without the change of the open and closed kinetics. PGF2alpha increased
the amplitudes of KV currents with a leftward shift of activation and
inactivation curves and a decrease of activation time constant. Our
results
suggest that the activation of KCa and KV channels, at least in part, may lead to attenuate or counteract vasoconstriction by PGF2alpha in middle cerebral artery.
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