Enzyme Analysis in Patients with Renal Stones Who Were Treated by Repeated Extracorporeal Shock Wave Lithotripsy

Oh, Soon Sig; Jung, Gyung Woo; Yoon, Jin Han

Abstract

Among the patients who underwent extracorporeal shock wave lithotripsy (Modulith SL 20, Karl Storz, Germany) for renal stones between December 1991 and July 1992, 33 patients were selected for study. Of 33 patients 23 had 1 session and 10 patients had 2 session after 48 hours. We measured 24 hours urinary N-acetyl-beta-D-glucosaminidase(NAG), lactate dehydrogenase (LDH), r-glutamyl transpeptidase (r-GTP) activity, urea, creatinine and protein and serum alkaline phosphatase (ALP), glutamic oxaloacetic transaminase(GOT), glutamic pyruvic transaminase (GPT), lactate dehydrogenase (LDH), r-glutamyl transpeptidase( r-GTP) activity, urea nitrogen(BUN), creatinine, albumin and globulin before and after extracorporeal shock wave lithotripsy(ESWL) for measurement as a marker of renal damage and extent of renal damage between one session group and two session group. Serum LDH and 24 hours urinary NAG activity is significantly increased after treatment and was still high on the 3rd day. Statistic significance was not found between 1 session group and 2 session group for serum LDH and 24 hours urinary NAG activity on the 1st and 3rd day post-ESWL. These results suggest that repeated ESWL after one session for renal stone did not significantly damage the kidney.