Korean J Urol.
1986 Jun;27(3):392-396.
Experimental Studies on the Induction of Cryptorchism with Estrogen
- Affiliations
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- 1Department of Urology, Yonsi University College of Medicine, Seoul, Korea.
Abstract
- Previous experimental studies on cryptorchism have been done with surgical manipulation which brought already descended gonads in the abdomen. However, the possibility of tissue damage with surgical manipulation has been discussed as a limitation of this procedure. In an effort to observe the possibility of the induction of cryptorchism with estrogen, Sprague-Dawley rats were injected intramuscularly with depoestradiol cypionate of various dosage schedule and timing of treatment. The results obtained were summarized as follows: 1. In cases treated with 0.5-2.0 mg/rat of depoestradiol cypionate at 2 weeks of pregnancy, stillbirth or death in 24hrs after birth resulted in offsprings. 2. Cryptorchism was not induced in all cases treated with 0.3mg/kg of depoestradiol cypionate irrespective of the age at treatment. 3. Cryptorchism was induced in .all cases treated with 0.3mg/rat of depoestradiol cypionate at 1 week after birth. This results might be used as a basis of the related and consecutive studies on cryptorchism.
