Clinical Application of Short Term Chemotherapy in the Genitourinary Tuberculosis

Sohn, Joon Woong; Chang, Sung Goo

Abstract

Since 1984, 9 months regimen of chemotherapy have been adopted for the treatment of 22 patients (15 men and 7 women) suffering from genitourinary tuberculosis. Age range of patients was from 16 years to 68 years with average of 34.7 years. Urine culture for AFB were positive in 12 patients (54.6 %) and the other patients were diagnosed by radiologic, cystoscopic and histopathologic examinations In all 12 patients who had positive urine culture for AFB, urine has been sterilized within 3 months after treatment. The surgical managements with chemotherapy were performed in 9 patients. Toxic hepatitis due to drugs developed in 1 patient. The cost of chemotherapeutics spent in long term chemotherapy was 3 to 4 times higher than in short term chemotherapy. `There were no relapse bacteriologically during the follow up periods (3 to 22 months, average 10.4 months), but one patient has undergone ureteroneocystostomy due to UVJ stricture after completion of chemotherapy.