Clinical Evaluation of Serum and Urinary Carcinoembryonic Antigen in Genitourinary tumor

Mo, Young Jong; Chang, Sae Kook

Abstract

Carcinoembryonic antigen(CEA) was measured by the enzyme immunoassay(EIA) technique in the serum and urine of 25 patients with non-tumor disease and 68 patients with several types of genitourinary tumor at the Department of Urology, Kyungpook National University Hospital during period from January 1982 to May, 1984. The results were as follows : 1. Mean serum and urine CEA levels in 24 normal controls were 3.97 ng/ml and 9.56 ng/ml. The upper limit of ""Normal"" for CEA levels was fixed at 2 standard deviation above the mean of normal controls. Therefore, we accept 9ng/ml and 23 ng/ml as the upper limit of normal for serum and urine 2. Mean serum and urine CEA levels in 21 patients with urinary infection were 5.70 ng/ ml and 21.14ng/ ml and incidence of positive results in serum and urine were 9.5% and 33%. Mean serum and urine CEA. levels in 68 patients with G-U tumor were 11.08ng/ ml and 49.12 ng/ ml and incidence of positive results in serum and urine were 32% and 34% 3. Mean serum and urine CEA levels in bladder ca were 13.78 ng/ ml and 60.43 ng/ ml being the highest elevation in G-U tumor, 12.74 ng/ ml and 53.60 ng/ ml in renal cell ca and 7.98 ng/ ml and 44.40ng/ ml in ureteral ca. Incidence of positive results of serum and urine in bladder ca were 38% and 38%, 23% and 38% in renal cell ca and 33% and 40% in ureteral ca. 4. Mean CEA levels and incidence of positive results in urine were correlated with the stage and grade of bladder ca. 5. Preoperative and postoperative serum and urine CEA measurements were useful in determining the completeness of tumor resection in patients with G-U tumor. However, in case of ileal conduit with cystectomy or incomplete resection of tumor mass, serum and urine CEA levels were increased postoperatively.