Neurointervention.  2008 Feb;3(1):1-6.

Problem Based Approach in Acute Ischemic Stroke

• Baik SK
• Kim YS

Abstract

Ischemic strokes result from thrombotic or embolic occlusion of one of the vessels that supply blood to the brain. The primary constituents of the initial thrombus are platelets and fibrin, with erythrocytes and other blood cells becoming trapped as thrombosis continues. Therefore, the recent improvements in therapy have focused on inhibiting platelets and dissolving fibrin. A new generation of thrombolytic agents (plasminogen activators) has been developed over the last decade. However, the clinical improvement has at best been marginal and the frequency of serious intracranial hemorrhage remains unchanged. Therefore, we have extensively reviewed the medical literature to determine the reason for the unsatisfactory clinical outcomes with current pharmacological therapies.

Keyword

Acute stroke treatment; Thrombolytic therapy; Mechanical thrombectomy

MeSH Terms

Blood Cells
Brain
Erythrocytes
Fibrin
Fibrinolytic Agents
Intracranial Hemorrhages
Stroke*
Thrombolytic Therapy
Thrombosis
Fibrin
Fibrinolytic Agents