Nucl Med Mol Imaging.  2007 Dec;41(6):546-552.

Comparison of the Results for Sentinel Lymph Node Mapping in the Breast Cancer Patients using 99mTc-Antimony Trisulfide Colloid, 99mTc-Tin Colloid, and 99mTc-Human Serum Albumin

• Jang SJ
• Moon SH
• Kim SK
• Kim BS
• Kim SW
• Chung KW
• Lee ES
• Kang KW

Abstract

PURPOSE: In the breast cancer patient, lymphatic mapping and sentinel lymph node biopsy are the most important procedure for axillary lymph node staging. We aimed to compare the three radiocolloids [99mTc-antimony trisulfide colloid (ASC), 99mTc-tin colloid (TC), and 99mTc-human serum albumin (HSA)] for sentinel lymph node mapping.
SUBJECTS AND METHODS
Totally, 397 patients with clinically N0 stage were enrolled. 99mTc-ASC was injected in 202 out of 397 patients, 99mTc-TC was injected in 120 patients, and 99mTc-HSA was injected in the remaining 75 patients. The sentinel lymph nodes were localized by lymphoscintigraphy and selected using intraoperative gamma probe. All sentinel lymph nodes were investigated by intraoperative pathologic consultation. The axillary lymph nodes which were harvested by the lymph node dissection were also investigated.
RESULTS
The patients of each group showed similar clinical characteristics. There were no significant differences (p>0.05) in the identification rate of sentinel lymph nodes (IR), false negative rate (FNR), and negative predictive value (NPV). The axillary lymphadenectomy revealed axillary lymph node metastases in those three groups (ASC-33.2%, TC-31.7%, HSA-22.7%). The IR, FNR, and NPV were not significantly different among those groups.
CONCLUSION
Those three 99mTc-labeled radiocolloids showed equivalent results in sentinel lymph node mapping of breast cancer.

Keyword

sentinel lymph node biopsy; lymph node dissection; breast cancer; technetium 99m; antimony trisulfide colloid; tin colloid; human serum albumin

MeSH Terms

Breast Neoplasms*
Breast*
Colloids*
Humans
Lymph Node Excision
Lymph Nodes*
Lymphoscintigraphy
Neoplasm Metastasis
Sentinel Lymph Node Biopsy
Technetium
Technetium Tc 99m Aggregated Albumin*
Colloids
Technetium
Technetium Tc 99m Aggregated Albumin