Yeungnam Univ J Med.  2001 Dec;18(2):246-252. 10.12701/yujm.2001.18.2.246.

Treatment of Henoch-Sch?nlein Purpura with Intravenous Immunoglobulin

• Chung HS
• Kim WD
• Lee ES
• Choi KH
• Park YH
• Kim YJ

• KMID: 1909958
• DOI: http://doi.org/10.12701/yujm.2001.18.2.246

Abstract

We report the result of a high-dose intravenous immunoglobulin therapy in a Henoch-Sch?nlein purpura patient with severe abdominal pain and nephrotic syndrom who did not respond to methylprednisolone pulse therapy. Kidney bbiopsy showed diffuse mesangial cell proliferative glomerulonephritis with fibrocellular crescent formation in approximately 50% of glomeruli. Mesangium of all glomeruli were strong positive for IgA and C3 antibodies. High-dose intravenous immunoglobulin treatment was introduced and dramatic improvement of gastrointestinal symptom and proteinuria as well as hematuria was noted. Immunoglobulin administration should be considered in Henoch-Schnlein purpura patients with sterois-resistant intractable dastrointestinal manifestation and renal involvenment.

Keyword

Henoch-Schonlein purpura; Nephrotic syndrome; Abdominal pain; Intravenous immunoglobulin

MeSH Terms

Abdominal Pain
Antibodies
Glomerulonephritis
Hematuria
Humans
Immunization, Passive
Immunoglobulin A
Immunoglobulins*
Kidney
Mesangial Cells
Methylprednisolone
Nephrotic Syndrome
Proteinuria
Purpura*
Purpura, Schoenlein-Henoch
Antibodies
Immunoglobulin A
Immunoglobulins
Methylprednisolone