Korean J Otolaryngol-Head Neck Surg.  2002 Jun;45(6):601-607.

Angiogenesis in the Head and Neck Squamous Cell Carcinoma

• Hong DK
• Kim KR
• Lee HS
• Park CK
• Park YU
• Jang SJ
• Tae K

Abstract

BACKGROUND AND OBJECTIVES: Angiogenesis is a necessary process for solid tumor to grow in human body, and thought to play an important role in metastasis. In some solid tumor such as the breast cancer and prostatic cancer, the angiogenesis is thought to be one of the most significant prognostic factors that predict the patient survival rate and metastasis. The purpose of this study is to define the significance of angiogenesis in the head and neck squamous cell carcinoma (HNSCC).
SUBJECTS AND METHOD
We measured the microvascular density (MVD) using immunohistochemistry with anti-CD34 antibody in 40 HNSCC. The maximal and average MVD was compared with the clinical parameters such as stage, cervical lymph node metastasis, recurrence, and survival rate, obtained through the retrospective review of the medical records.
RESULTS
1) The maximal and average MVD correlated with overall stage, T stage and N stage statistically. The MVD were increased according to the increasement of the T and N stage. 2) The maximal and average MVD showed a significant relationship with 3 year survival rate. 3) There were no relationship between maximal and average MVD and local or regional recurrence.
CONCLUSION
The maximal and average MVD may be a significant prognostic factors which can predict the survival rate of the patients with HNSCC.

Keyword

Angiogenesis factor; Carcinoma; Squamous cell; CD34

MeSH Terms

Angiogenesis Inducing Agents
Breast Neoplasms
Carcinoma, Squamous Cell*
Head*
Human Body
Humans
Immunohistochemistry
Lymph Nodes
Medical Records
Neck*
Neoplasm Metastasis
Prostatic Neoplasms
Recurrence
Retrospective Studies
Survival Rate
Angiogenesis Inducing Agents