Ann Surg Treat Res.  2014 Aug;87(2):61-65. 10.4174/astr.2014.87.2.61.

Long-term outcomes of intraoperative and perioperative albendazole treatment in hepatic hydatidosis: single center experience

• Karabulut
• Ozbalci GS
• Kesicioglu T
• Tarim IA
• Lap G
• Kamali Polat A
• Karabicak
• Erzurumlu

• KMID: 1882832
• DOI: http://doi.org/10.4174/astr.2014.87.2.61

Abstract

PURPOSE
The aim of this study was to evaluate long-term outcome of the intraoperative and perioperative albendazole (ALB) treatment on the recurrence and/or secondary hydatidosis.
METHODS
One hundred and one patients with hepatic hydatidosis were treated intraoperatively and perioperatively with ALB, in addition to surgery. Perioperative ALB treatment was given in a dose of 12-15 mg/kg/day. The ALB treatment was started 13.27 +/- 14.34 days before the surgery, and it was continued for 4.39 +/- 3.11 months postoperatively. A total of 1.7 microg/mL of ALB solution was used as a protoscolidal agent. The follow-up period was 134.55 +/- 51.56 months.
RESULTS
Four patients died, with only one death was secondary to hydatid disease (cerebral eccinococcus). There was only one recurrence (1%) of hepatic hydatidosis. Early and late morbidity rates were 8.91% and 7.92%, respectively.
CONCLUSION
Our results suggest that intraoperative and perioperative ALB is effective for the prevention of hepatic hydatidosis recurrence and/or secondary hydatidosis.

Keyword

Albendazole; Hepatic echinococcosis; Recurrence

MeSH Terms

Albendazole*
Echinococcosis
Echinococcosis, Hepatic*
Follow-Up Studies
Humans
Recurrence
Albendazole

Reference

1. Bekhti A, Schaaps JP, Capron M, Dessaint JP, Santoro F, Capron A. Treatment of hepatic hydatid disease with mebedazole: preliminary results in four cases. Br Med J. 1977; 2:1047–1051.

2. Saimot AG, Meulemans A, Cremieux AC, Giovanangeli MD, Hay JM, Delaitre B, et al. Albendazole as a potential treatment for human hydatidosis. Lancet. 1983; 2:652–656.

3. Morris DL, Dykes PW, Marriner S, Bogan J, Burrows F, Skeene-Smith H, et al. Albendazole--objective evidence of response in human hydatid disease. JAMA. 1985; 253:2053–2057.

4. Khuroo MS, Dar MY, Yattoo GN, Zargar SA, Javaid G, Khan BA, et al. Percutaneous drainage versus albendazole therapy in hepatic hydatidosis: a prospective, randomized study. Gastroenterology. 1993; 104:1452–1459.

5. Saimot AG. Medical treatment of liver hydatidosis. World J Surg. 2001; 25:15–20.

6. Polat C, Dervisoglu A, Hokelek M, Yetim I, Buyukkarabacak Y, Ozkutuk Y, et al. Dual treatment of albendazole in hepatic hydatidosis: new therapeutic modality in 52 cases. J Gastroenterol Hepatol. 2005; 20:421–425.

7. Gharbi HA, Hassine W, Brauner MW, Dupuch K. Ultrasound examination of the hydatic liver. Radiology. 1981; 139:459–463.

8. Dervisoglu A, Erzurumlu K, Tac K, Arslan A, Gursel M, Hokelek M. Should intraoperative ultrasonography be used routinely in hepatic hydatidosis? Hepatogastroenterology. 2002; 49:1326–1328.

9. Erzurumlu K, Ozdemir M, Mihmanli M, Cevikbas U. The effect of intraoperative mebendazole-albendazole applications on the hepatobiliary system. Eur Surg Res. 1995; 27:340–345.

10. Erzurumlu K, Sahin M, Selcuk MB, Yildiz C, Kesim M. Intracystic application of mebendazole solution in the treatment of liver hydatid disease. Preliminary report of two cases. Eur Surg Res. 1996; 28:466–470.

11. Prousalidis J, Kosmidis CH, Fahantidis E, Harlaftis N, Aletras O. Surgical treatment of multiple cystic echinococcosis. HPB (Oxford). 2004; 6:110–114.

12. Mirelis CG, Bekiaridou KA, Bougioukas IG, Xanthoulis AI, Tsalkidou EG, Nannou G, et al. Long-term results of surgical treatment of hydatid disease. Acta Chir Belg. 2006; 106:684–687.

13. Aydin U, Yazici P, Onen Z, Ozsoy M, Zeytunlu M, Kilic M, et al. The optimal treatment of hydatid cyst of the liver: radical surgery with a significant reduced risk of recurrence. Turk J Gastroenterol. 2008; 19:33–39.

14. Atmatzidis K, Koutelidakis I, Papaziogas B, Alexandrakis A, Chatzimavroudis G, Grigoriou M, et al. Primary hydatid cyst of the thigh. Chirurgia (Bucur). 2006; 101:419–421.

15. Yagci G, Ustunsoz B, Kaymakcioglu N, Bozlar U, Gorgulu S, Simsek A, et al. Results of surgical, laparoscopic, and percutaneous treatment for hydatid disease of the liver: 10 years experience with 355 patients. World J Surg. 2005; 29:1670–1679.

16. Secchi MA, Pettinari R, Mercapide C, Bracco R, Castilla C, Cassone E, et al. Surgical management of liver hydatidosis: a multicentre series of 1412 patients. Liver Int. 2010; 30:85–93.

17. Erzurumlu K, Yucel Y, Tezelman S. The effectiveness and late results of tube drainage in hepatic hydatidosis (an analysis of 21 cases). Med Bulletin of Ist Med Fac. 1991; 54:283–290.

18. Xiao SH, Feng JJ, Guo HF, Jiao PY, Yao MY, Jiao W. Effects of mebendazole, albendazole, and praziquantel on fumarate hydratase, pyruvate kinase, and phosphoenolpyruvate carboxykinase of Echinococcus granulosus cyst wall harbored in mice. Zhongguo Yao Li Xue Bao. 1994; 15:69–72.

19. Cakmakçi M, Sayek I. Prophylactic effect of albendazole in experimental peritoneal hydatidosis. Hepatogastroenterology. 1992; 39:424–426.

20. Tsimoyiannis EC, Siakas P, Moutesidou KJ, Karayianni M, Kontoyiannis DS, Gossios KJ. Perioperative benzimidazole therapy in human hydatid liver disease. Int Surg. 1995; 80:131–133.

21. Aktan AO, Yalin R. Preoperative albendazole treatment for liver hydatid disease decreases the viability of the cyst. Eur J Gastroenterol Hepatol. 1996; 8:877–879.

22. Horton RJ. Albendazole in treatment of human cystic echinococcosis: 12 years of experience. Acta Trop. 1997; 64:79–93.

23. Liu Y, Wang X, Wu J. Continuous long-term albendazole therapy in intraabdominal cystic echinococcosis. Chin Med J (Engl). 2000; 113:827–832.

24. Chai J, Menghebat , Wei J, Deyu S, Bin L, Jincao S, et al. Observations on clinical efficacy of albendazole emulsion in 264 cases of hepatic cystic echinococcosis. Parasitol Int. 2004; 53:3–10.

25. Morris DL, Chinnery JB, Hardcastle JD. Can albendazole reduce the risk of implantation of spilled protoscoleces? An animal study. Trans R Soc Trop Med Hyg. 1986; 80:481–484.

26. Penicaut B, Maugein P, Maisonneuve H, Rossignol JF. Pharmacokinetics and urinary metabolism of albendazole in man. Bull Soc Pathol Exot Filiales. 1983; 76:698–708.

27. Marriner SE, Bogan JA. Pharmacokinetics of albendazole in sheep. Am J Vet Res. 1980; 41:1126–1129.

28. Erzurumlu K, Hokelek M, Baris S, Sahin M, Birinci A, Amanvermez R, et al. Effect of albendazole sulfoxide solution on the scolices and the hepatobiliary system. Eur Surg Res. 1998; 30:433–438.

29. Wilson JF, Rausch RL. Mebendazole and alveolar hydatid disease. Ann Trop Med Parasitol. 1982; 76:165–173.

30. Avgerinos ED, Pavlakis E, Stathoulopoulos A, Manoukas E, Skarpas G, Tsatsoulis P. Clinical presentations and surgical management of liver hydatidosis: our 20 year experience. HPB (Oxford). 2006; 8:189–193.