Kosin Med J.  2014 Jun;29(1):63-68. 10.7180/kmj.2014.29.1.63.

A Case of Seizure and Metabolic Acidosis Due to Renal Adjustment Dosage of Isoniazid in an Elderly Woman

• Shin YS
• Sim EH
• Yeo CW
• Kang JD
• Kim JY
• Park SJ

• KMID: 1882441
• DOI: http://doi.org/10.7180/kmj.2014.29.1.63

Abstract

Isoniazid is one of the most commonly used antituberculosis drug. Acute into xication is characterized by repetitious convulsions, high anion gap metabolic a cidosis and coma. The basis of theraphy consists of parental pyridoxine admi nistration in a dose equivalent to that of isoniazid ingested. Here we present a case of seizure and metabolic acidosis due to only renal adjustment dosage of Isoniazid in an elderly woman.

Keyword

Isoniazid; Metabolic acidosis; Pyridoxine; Seizure

MeSH Terms

Acid-Base Equilibrium
Acidosis*
Aged*
Coma
Female
Humans
Isoniazid*
Parents
Pyridoxine
Seizures*
Isoniazid
Pyridoxine

Figure

• 

  Fig. 1. Non-enhanced abdominal CT scan demonstrates lytic destructive change in Thoracic vertebral body.

• 

  Fig. 2. T2-weighted sagittal MRI of spine demonstrates destruction of T10, T 11, T12 bodies due to spinal tuberculosis and secondary to abscess formation.

• 

  Fig. 3. Skin lesions of erythema and dry patches were observed on the buttock and abdomen.

• 

  Fig. 4. There is no gross abnormality in T2-weighted magnetic resonance imaging of brain.

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