Tuberc Respir Dis.  2007 Jul;63(1):59-66. 10.4046/trd.2007.63.1.59.

Safety and Significance of Surgical Lung Biopsy for Interstitial Lung Disease

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon, Korea. sykim@cnu.ac.kr

Abstract

BACKGROUND: Surgical lung biopsy is required to establish the etiology and stage of interstitial lung disease(ILD). and this procedure can be safe and meaningful for making clinical decisions. We wanted to determine the safety of surgical lung biopsy(SLB) in patients with interstitial lung disease(ILD).
METHODS
We conducted a retrospective review of 40 patients with suspected ILD and they underwent surgical lung biopsy from January 2001 to June 2006 at Chungnam University Hospital. We analyzed retrospectively according to their age, gender, pulmonary function, chest tube duration, the arterial blood gases, the procedural technique, and the requirement for supplemental oxygen and mechanical ventilation(MV) at the time of SLB.
RESULTS
The mean age of the patients was 56.4+/-16.13 years(range: 21 to 77 years). Overall, the 30-day and 90-day mortality rates were 15% and 20%, respectively. The predictors of perioperative mortality were either the need for mechanical ventilation(MV) at the time of SLB or the need for supplemental oxygen prior to undergoing SLB. Among the 32 patients who were 90-day survivors, the proportion of those patients using the oxygen supplement was 28.1% (n=9). All 8 patients who were 90-day non-survivors used oxygen supplement (p=0.000). The use of the MV was 12.5% (n=4) in the 90-day survivors (n=32) and 62.5% (n=5) in the 90-day non-survivors (n=8); there was a significant difference between the 90-day survivors and non-survivors (p=0.000).
CONCLUSION
Patients who require MV and supplemental oxygen are associated with an increased risk for death following SLB.

Keyword

Surgical lung biopsy; Interstitial lung disease; Safety
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