Allergic Immune Reaction in Recurrent Aphthous Ulceration by Multiple Allergosorbent Test(MAST)

Yum, Dong Jin; Park, Sang Hyun; Kim, IL Kang; Kang, Jae Ho; Kim, Chun Dong; Park, Sung Ho

Abstract

BACKGROUND AND OBJECTIVES: Recurrent aphthous ulceration (RAU) is most common among benign oral mucosal diseases, but its pathogenesis is not clearly defined yet. We aimed to evaluate the allergic reaction and identify the allergen by using the multiple allergosorbent test (MAST).
SUBJECTS AND METHOD
We selected a total of 20 patients with RAU. RAU was not diagnosed by biopsy but by clinical findings, and MAST was performed in all patients. Parameters used were total IgE concentration, type of positive allergens, and the specific IgE concentration.
RESULTS
The results were as follows: 1) The total IgE concentration was increased more in the RAU group than in the control group (p<0.05). 2) The type of positive allergens was multiple and had more even distribution in the RAU group than in the control group (p<0.05). 3) The specific IgE concentration according to the positive allergen was higher in the RAU group than in the control group (p<0.05).
CONCLUSION
Allergic reactions could be invol-ved in the pathogenesis of RAU. The pathomechanism of allergic reaction to the RAU and the feasibility of treatment options such as avoidance therapy, the immune therapy, and the antihistamine usage need further study.