Is the Serum Anti-Helicobacter pylori IgG Antibody Titer Valuable in Differentiating the Gastroduodenal Diseases?

Choi, Ji Yong; Kim, Hak Yang; Yoon, Duck Hyoung; Rho, Seung Hyuk; Kim, Soo Jin; Lee, Ja Young; Baik, Gwang Ho; Kim, Auk; Lee, Jin Heon; Kim, Yong Bum; Kim, Woo Joong; Yoo, Jae Young

Abstract

BACKGROUND/AIMS: Among the diagnostic methods to detect Helicobacter pylori (H. pylori) infection, serological test is a noninvasive, safe, and inexpensive method in clinical practice. This study was performed to determine whether the titer of anti-H. pylori IgG antibody was correlated with endoscopic findings of gastroduodenal diseases, gastric ulcer stage, and age.
METHODS
Two hundred and eighteen patients who were H. pylori positive by serological method and received gastroduodenal endoscopy were enrolled. All patients had the titers of anti-H. pylori IgG antibody > 300 U/mL. We compared the antibody titer according to gastroduodenal diseases, peptic ulcer stage, and age group.
RESULTS
There was no statistically significant difference between serum anti-H. pylori IgG antibody titer according to gastroduodenal diseases (chronic gastritis, 999.8+/-120 U/mL; gastric ulcer, 1043+/-155.6 U/mL; duodenal ulcer, 1018.5+/-121.9 U/mL; gastric cancer, 1351+/-266 U/mL; p=0.504). No significant difference in the anti-H. pylori IgG antibody titer was observed according to peptic ulcer stage (p=0.065) and age (p=0.791).
CONCLUSIONS
The serum anti-H. pylori IgG antibody titer is not valuable in differentiating the gastroduodenal diseases.