Korean J Blood Transfus.
2001 Jun;12(1):63-66.
A case of Intravascular Hemolytic Transfusion Reaction due to Anti-Jkb
- Affiliations
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- 1Department of Clinical Pathology, Metro Hospital, Ahnyang, Korea.
- 2Obstetrics and Gynecology, Metro Hospital, Ahnyang, Korea.
- 3Internal Medicine, Metro Hospital, Ahnyang, Korea.
- 4Department of Clinical Pathology, Yonsei University College of Medicine, Seoul, Korea.
Abstract
- We report a hemolytic transfusion reaction with acute intravascular hemolysis due to anti-Jkb in a 49-year-old woman with uterine myoma. A patient experienced chills, fever, and red color urine following the transfusion of 1.25 units of packed red cells, shown to be compatible by the conventional cross-matching tube method. She had been received two units transfusion 3 weeks ago and there was no transfusion reaction at that time. One day after transfusion, her laboratory data showed total bilirubin 2.7 mg/dL, LDH 2,310 IU/L, and a trace positive direct antiglobulin test. Irregular antibody screening test was negative by the conventional tube methods but anti-Jkb was identified by column agglutination method. The presence of anti-Jkb provided an explanation for the acute hemolytic reaction. The hemolytic transfusion reaction was secondary responses following the previous transfusion. She showed severe hemoglobinuria, but renal failure did not develop and she was fully recovered with maintaining adequate renal output with IV diuretics.
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