Korean J Androl.  2000 Apr;18(1):59-62.

Changes of Penile Sensitivity after Intracavernosal Pharmacotherapy in Patients with Premature Ejaculation

• Sohn DW
• Shim KS
• Park HS
• Park NC

Abstract

PURPOSE
To evaluate the changes in penile sensitivity during the erectile response and their role in premature ejaculation, We investigated the penile sensitivity of patients with premature ejaculation or impotence and normal volunteers.
PATIENTS AND METHODS
Penile sensitivity was evaluated by vibratory threshold in 19 men with premature ejaculation (PE group; average age 37.8 years), 14 men with impotence (Impo group; 41.8 years), and 13 normally potent male volunteers (control group; 30.0 years). Vibratory thresholds were recorded three times at the glans and shaft during the flaccid, tumescence, and rigid phases of penile erection using a biothesiometer (Model PVD; Bio-medical Instruments Co., USA). Artificial penile erection was induced by intracavernosal injection of prostaglandin E1 5-20 micro gram.
RESULTS
Penile sensitivity revealed no significant difference among the three groups during the flaccid phase but was significantly lower in the Impo and control groups than in the PE group during the tumescence and rigid phases (p<0.05). Thus, the PE group had penile hyperesthesia in comparison with the other groups during erection. The penile sensitivity values in the three groups showed no significant differences according to location of the penis during the flaccid, tumescence and rigid phases.
CONCLUSION
The pathogenesis of premature ejaculation seems to involve peripheral nerve sensitivity rather than being a reaction to the hypoxic state on full erection.

Keyword

Penile erection; Premature ejaculation

MeSH Terms

Alprostadil
Drug Therapy*
Erectile Dysfunction
Healthy Volunteers
Humans
Hyperesthesia
Male
Penile Erection
Penis
Peripheral Nerves
Premature Ejaculation*
Volunteers
Alprostadil