J Lipid Atheroscler.  2013 Dec;2(2):61-67. 10.12997/jla.2013.2.2.61.

The Inflammation Markers According to the Presence of Coronary Artery Disease in Patients with Peripheral Artery Disease

• Kim SY
• Kang WY
• Shin JH
• Youn BR
• Jung IH
• Nam DI
• Kang C
• An HJ
• Lee SS
• Song HY
• Kang H
• Cho SC
• Hwang SH
• Kim W

• KMID: 1845570
• DOI: http://doi.org/10.12997/jla.2013.2.2.61

Abstract

OBJECTIVE
Prevalence of coronary artery disease (CAD) has been reported to be high in patients with atherosclerotic peripheral artery disease (PAD) in lower extremities. Various inflammatory markers have been known to be associated with CAD. The aim of study was to explore the role of inflammatory makers for CAD in patients with PAD.
METHODS
A total of 346 PAD patients (71.51+/-9.41 years, 337 males) who underwent percutaneous transluminal angioplasty from June 2006 to April 2012 were included in this study. Patients were divided into the Group I (PAD with CAD: n=151, 149 males) and the Group II (PAD without CAD: n=195, 188 males).
RESULTS
Among 346 patients, 149 patients had CAD (43.6%). The prevalence of diabetes mellitus (DM) (p=0.023) and smoking (p=0.010) were significantly higher in the group I when compared withthe group II. The level of high sensitivity C-reactive protein (hs-CRP) increased (p<0.001) significantly in the group I compared with the group II. By multiple logistic regression analysis, smoking (odds ratio [OR]=1.991, 95% confidence interval [CI]: 1.162-3.411; p=0.012), DM (OR=1.922, 95% CI: 1.145-3.228; p=0.015), hs-CRP (> or =3.0 mg/dL) (OR=2.595, 95% CI: 1.548-4.350, p<0.001), and age (OR=0.645; 95% CI, 0.454-0.915; p=0.014) were independent predictors for the development of CAD in PAD patients.
CONCLUSION
43.6% of patients with PAD also had CAD, and the predictors of CAD were smoking, DM, and high level of hs-CRP.

Keyword

Coronary artery disease; Peripheral arterial disease; Diabetes mellitus; Inflammation; Smoking

MeSH Terms

Angioplasty
C-Reactive Protein
Coronary Artery Disease*
Coronary Vessels*
Diabetes Mellitus
Humans
Inflammation*
Logistic Models
Lower Extremity
Peripheral Arterial Disease*
Prevalence
Smoke
Smoking
C-Reactive Protein
Smoke

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