J Korean Thyroid Assoc.  2013 Nov;6(2):91-95. 10.11106/jkta.2013.6.2.91.

Aberrant L1 Cell Adhesion Molecule Expression in Cancer: In View of Proliferation, Migration and Invasion

• Kim KS

• KMID: 1845378
• DOI: http://doi.org/10.11106/jkta.2013.6.2.91

Abstract

L1 cell adhesion molecule (L1CAM) is a 220-kDa type I membrane glycoprotein and is normally expressed in neuronal cells, endothelial cells, and renal epithelial cells. Recent clinical studies demonstrated aberrant L1CAM expression in various cancers, especially at the invasive area of cancers. L1CAM has a key role in tumorigenesis, tumor invasion, and it is associated with a poor prognosis of cancer. Anaplastic thyroid carcinoma (ATC) has a highly poor outcome and it is resistant to conventional treatment. In this review, I discuss the biological role of L1CAM in proliferation, migration, and invasion in the ATC.

Keyword

L1CAM; Anaplastic thyroid carcinoma

MeSH Terms

Cell Transformation, Neoplastic
Endothelial Cells
Epithelial Cells
Membrane Glycoproteins
Neural Cell Adhesion Molecule L1*
Neurons
Prognosis
Thyroid Neoplasms
Membrane Glycoproteins
Neural Cell Adhesion Molecule L1

Figure

• 

  Fig. 1. Structure of L1CAM.

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  Fig. 2. Interaction of L1CAM.

Reference

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