Korean J Urol.  2013 Aug;54(8):555-557. 10.4111/kju.2013.54.8.555.

Squamous Cell Carcinoma in Exstrophy of the Bladder

• Sharma PK
• Pandey PK
• Vijay MK
• Bera MK
• Singh JP
• Saha K

• KMID: 1840470
• DOI: http://doi.org/10.4111/kju.2013.54.8.555

Abstract

Exstrophy of the bladder is a rare congenital anomaly with an incidence of about 1 per 50,000 newborns. The malignant potential of the exstrophied bladder mucosa is well known; 95% are adenocarcinomas, and 3% to 5% are squamous cell carcinomas. Most of the malignant tumors (60%) associated with an exstrophy of the bladder occur during the fourth and fifth decades of life. Of the remaining, about 20% each occur after 60 years and before 40 years. Here we present a case in which squamous cell carcinoma developed in an unrepaired exstrophy of the bladder. We present the management of the case and a brief review of the literature.

Keyword

Bladder exstrophy; Squamous cell carcinoma; Urinary bladder neoplasms

MeSH Terms

Adenocarcinoma
Bladder Exstrophy
Carcinoma, Squamous Cell
Humans
Incidence
Infant, Newborn
Mucous Membrane
Urinary Bladder
Urinary Bladder Neoplasms

Figure

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  FIG. 1 Preoperative photograph of the patient showing the hemispherical growth with an irregular surface.

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  FIG. 2 Intraoperative photograph showing the skin incision used for the modified groin flap.

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  FIG. 3 Immediate postoperative photograph showing the abdominal wall defect covered with a modified groin flap.

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  FIG. 4 Photograph of the patient after 5 months of follow-up showing a well-healed modified groin flap and excellent take of the skin graft at the secondary defect site.

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  FIG. 5 Histopathological picture of the case (H&E, ×400) showing well-differentiated squamous cell carcinoma.

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